Re-contacting minors enrolled in research upon their reaching the age of majority or maturity to seek their autonomous consent to continue their participation is considered an ethical requirement. This issue has generally been studied in the context of minors who are actively involved in the research. However, what becomes of this issue when the minor has been withdrawn from the research or has been lost to follow-up? May researchers re-contact the minor at the age of majority or maturity under these (...) circumstances to seek the consent of the minor to re-join the research? In this paper, we explore the ethical permissibility of recontacting minors whose participation in research has ended, once they have reached the age of majority or maturity. In particular, we identify scenarios in which the participation of a minor in a research project may end and discuss factors that can help determine such an ethical permissibility. Finally, we discuss the practical and ethical challenges of re-contact and present re-consent models that may be used by researchers. (shrink)

This paper addresses the problem of ‘premature consent’. The term ‘premature consent’ denotes patient decisions that are: formulated prior to discussion with the appropriate healthcare professional ; based on information from unreliable sources ; and resolutely maintained despite the HCP having provided alternative reliable information. HCPs are not obliged to respect premature consent patients’ demands for unindicated treatments. But why? What is it that premature consent patients do or get wrong? Davis has argued that premature consent patients are incompetent and (...) misinformed. We argue that this view is not sustainable. A more plausible position asserts that premature consent threatens the integrity of the medical profession. We argue that this gives rise to a negative patient duty which premature consent patients fail to honour. We argue for a further positive duty of good faith engagement in shared decision-making. This implies willingness to potentially revise or justify one’s evaluative bases. Fundamentally, the problem with premature consent patients is that certain of their evaluative bases are not open to revision. They therefore fail in their duty to participate faithfully in the shared decision-making process. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

Neuroenhancement offers the prospect of improving the cognitive, emotional and motivational functions of healthy individuals. Of all the conceivable interventions, psychopharmacology provides the most readily available ones, such as antidepressants which are thought to make people “better than well”. However, up until now, whether they possess such an enhancing ability remains controversial and therefore in this systematic review we will evaluate the effect and safety of modern antidepressants in healthy individuals. A search of MEDLINE and EMBASE databases and cross-references was (...) carried out and the pharmaceutical industry was contacted for suitable data. Trials published in any language through the third week of July 2007 were regarded. Included were single or double blind randomised or quasi-randomised controlled trials that compared a placebo to one or more of the following antidepressants: bupropion, citalopram, duloxetine, escitalopram, fluoxetine, fluvoxamine, moclobemide, paroxetine, reboxetine, sertraline or venlafaxine in any dose or dosing schedule. Eligible studies were those involving healthy people of any age and either sex who showed no evidence of a psychiatric disorder, cognitive decline or other disease. One hundred thirty-five articles met our inclusion criteria reporting single dose trials and trials with repeated drug administration. Sixty-five of these articles were eligible for a statistical analysis. Based on a linear mixed model, a meta-analysis and a fixed effects meta-regression were performed. Pooling of results by meta-analysis was stratified by the outcome measures mood, emotional processing, wakefulness, attention, memory, and executive functions. On a significance level of p < 0.05 the following significant results emerged: After a single dose of an antidepressant, a significant effect was shown in two of the analysed outcomes. Firstly, there was a small yet significant negative effect on wakefulness. On memory, a positive effect after several measurements was found, but this result could be traced to the results of the one study out of all included studies, which had that many assessment points. The analysis of trials with repeated drug administration yielded the following effects: on mood, a non-significant positive effect was detected that was continuously increasing and reached significance at the last assessment point. Regarding attention, a fluctuating effect was found, while for memory, the fact that the two groups started with a group difference confounded the results. For wakefulness there was no significant effect in any particular assessment point, while for emotional processing and executive functions, the small number of studies did not allow for any effect to emerge. In summary, no consistent evidence for enhancing effects of antidepressants could be found. There is little evidence so far to support the popular opinion that antidepressants have a positive effect on the mood of healthy individuals after repeated administration. No evidence of a significant adverse event profile could be found. The studies included in this systematic review not only provide insufficient evidence for or against any effect in healthy people, but they are inapt to be used for answering this question. This may be explained by the fact that most of them were not designed to examine neuroenhancement effects. The growing public interest in neuroenhancement stands in stark contrast to the paucity of data on enhancement effects of available psychopharmacological agents. (shrink)

The influence of religious beliefs to several leading mathematicians in early Soviet years, especially among members of the Moscow Mathematical Society, had drawn the attention of militant Soviet marxists, as well as Soviet authorities. The issue has also drawn significant attention from scholars in the post-Soviet period. According to the currently prevailing interpretation, reported purges against Moscow mathematicians due to their religious inclination are the focal point of the relevant history. However, I maintain that historical data arguably offer reasons to (...) cast reasonable doubts on this interpretation. In this paper, by reviewing the relevant literature, I raise some methodological and philosophical concerns, in an attempt to contribute to a better understanding of the issue. I maintain that an efficient line of reasoning is to discuss issues in the context of their making, taking into consideration the specific features of each era’s culture. Thus, by focusing on P.A. Nekrasov’s case, I attempt to point to an alternative interpretation, in which the different treatment of religious inclined mathematicians by Soviet authorities is explained in the context of the ideological confrontation between two contrasting worldviews, as part of the ongoing class war in the several phases of Soviet history. (shrink)

In this paper I point out main shortfalls of the three main families of theories of perception and I propose a sort of inferential realism. In addition, I argue that there cannot be a scientific variant of direct realism and illustrate this point with reference to P.F.Strawson's attempt to reconcile, not naïve realism and the scientific variant as he amounts to, but rather, direct and indirect realism. I draw the distinction between four cases of illusion, and I refer to one (...) of these, namely to the case of veridical illusion, to show that Strawson's view, put in terms of the Fregean sense-reference distinction, fails. As regards indirect realism, I argue against the representationalist account and the Lockean picture of primary and secondary qualities. Phenomenalism is rejected in terms of the impossibility to identify an object throughout different contexts and I suggest that what is for x to be that x in different contexts can be given only by a realist analysis of a material object. Finally, I provide an account of what it is for A to perceive that x with respect to different contexts and I conclude with what conditions should veridical perception meet and therefore propose the framework of a new theory of perception. (shrink)

The Byzantine dreambook known in the tradition as The Oneirocriticon of Achmet has had a long and influential history both in its field and in scholarship. It is the longest of the eight surviving Byzantine books on dream interpretation, and most likely also the oldest. It was compiled during the Macedonian renaissance—specifically, the two termini of 843 and 1075 can be established—possibly in the reign of Leo VI (r. 886–912), to whom it may have been dedicated, and possibly through the (...) influence of his Arab minister Samonas. It was translated early into Latin, in 1176 (by contrast, the famous ancient dreambook of Artemidorus was not translated until 1539), and “through this translation found its way into several European and vernacular languages from the late thirteenth century onward” (p. 4). The scholarly study of the work began in 1577, with the preface Johann Loewenklau wrote for his Latin translation of the Greek text, and continued apace to this day. The book by Maria Mavroudi under review here, from which this information is taken (chapter 1), is the latest in a long series of studies. It is also the most exhaustive and meticulous in its research and the first fully to take into account, in a professional and exemplary manner, the Arabic sources of the work. Exhaustive, but perhaps also exhausting—one may object that 471 pages of text (exclusive of prefatory material and bibliographies and indices) for a study of a mere dreambook may be too many, though apparently necessary, for Mavroudi's book contends against the weight of previous scholarship and offers much needed correctives. (shrink)

In drawing on Poincare’s conventionalism, Cassirer’s neo-Kantianism, Duhem’s methodological conservatism, and Russell’s holist doctrine of scientific knowledge, Worrall (1989) launched in his classical paper a new position in realism debate. The champions of structural realism have managed to combine a sense in which the development of science is cumulative with a picture of theory change that coheres with the argument of the “pessimistic meta-induction”. Twenty two years after the publication of Worrall’s paper, the volume under review presents an exciting recapitulation (...) of the structuralist movement’s main achievements. The recapitulation is most welcome, since from the very outset of its development not only did structural realism oppose the forms of logical reductionism, but it also got its emancipation as a philosophical position through suggesting an alternative to van Fraassen’s constructive empiricism, while at the same time provoking a transformation of the latter into structu .. (shrink)

The three papers which follow this meeting report by Paul J. Friedman, Daniel Steiner, and Joost P. H. Drenth were presented at the symposium reviewed above.

The three papers which follow this meeting report by Paul J. Friedman , Daniel Steiner , and Joost P. H. Drenth were presented at the symposium reviewed above.

Bullying often results in negative coping in victims, including an increased consumption of alcohol. Recently, however, an increase in alcohol use has also been reported among perpetrators of bullying. The factors triggering this pattern are still unclear. We investigated the role of empathy in the interaction between bullying and alcohol use in an adolescent sample (IMAGEN) at age 13.97 (±0.53) years (baseline (BL), N = 2165, 50.9% female) and age 16.51 (±0.61) years (follow-up 1 (FU1), N = 1185, 54.9% female). (...) General empathic distress served as a significant moderator of alcohol use in perpetrators (F9, 493 = 17.978, p < 0.01), which was specific for males and FU1. Male perpetrators, who are generally less sensitive to distress, might thus be more vulnerable to alcohol abuse. (shrink)

Extensive research has demonstrated that rs1360780, a common single nucleotide polymorphism within the FKBP5 gene, interacts with early-life stress in predicting psychopathology. Previous results suggest that carriers of the TT genotype of rs1360780 who were exposed to child abuse show differences in structure and functional activation of emotion-processing brain areas belonging to the salience network. Extending these findings on intermediate phenotypes of psychopathology, we examined if the interaction between rs1360780 and child abuse predicts resting-state functional connectivity (rsFC) between the amygdala (...) and other areas of the salience network. We analyzed data of young European adults from the general population (N = 774; mean age = 18.76 years) who took part in the IMAGEN study. In the absence of main effects of genotype and abuse, a significant interaction effect was observed for rsFC between the right centromedial amygdala and right posterior insula (p <.025, FWE-corrected), which was driven by stronger rsFC in TT allele carriers with a history of abuse. Our results suggest that the TT genotype of rs1360780 may render individuals with a history of abuse more vulnerable to functional changes in communication between brain areas processing emotions and bodily sensations, which could underlie or increase the risk for psychopathology. (shrink)

Sabine Fourrier et al. Le dépot archaïque d'Amathonte, III. Les petits objets p. 67-118 Cet article présente les petits objets découverts dans un remblai d'époque archaïque, déposé contre le rempart Nord de la ville basse d'Amathonte. Le matériel, riche et varié, reflète les différentes fonctions du palais, dont il provient. Plusieurs types sont inédits ou seulement attestés parmi les trouvailles du palais de l'acropole. Certaines catégories, comme les figurines de terre cuite ou les marques incisées sur vases, sont particulièrement bien (...) représentées. Malgré leur aspect souvent fragmentaire, ces objets donnent une vue d'ensemble du mobilier que contenait le palais archaïque d'Amathonte. (shrink)

Keith Thomas: Gerald Edward Aylmer, 1926-2000 Adrian Hollis: William Spencer Barrett, 1914-2001 Bruce Williams: Charles Frederick Carter, 1919-2002 Malcolm Mackintosh: John Erickson, 1929-2002 J. H .R. Davis: Raymond William Firth, 1901-2002 F. M. L. Thompson: Hrothgar John Habakkuk, 1915-2002 A. W. Price: Richard Mervyn Hare, 1919-2002 Hugh Lloyd-Jones: Geoffrey Stephen Kirk, 1921-2003 Michael Lapidge and Peter Matthews: Vivien Anne Law, 1954-2002 Ann Moss: John Lough, 1913-2000 Terence Cave: Ian Dalrymple McFarlane, 1915-2002 Ludwig Paul: David Neil MacKenzie, 1926-2001 Peter Birks: John (...) Kieran Barry Moylan Nicholas, 1919-2002 Jonathan Shepard: Dimitri Dimitrievich Obolensky, 1918-2001 David Cannadine: John Harold Plumb, 1911-2001 Daniel Waley: Nicolai Rubinstein, 1911-2002 Ian Wood: John Michael Wallace-Hadrill, 1916-1985 R. G. M. Nisbet: William Smith Watt, 1913-2002 G. W. Bernard: Richard Bruce Wernham, 1906-1999. (shrink)

In this work, I have compared the views of Hans Georg Gadamer and Emmanuel Levinas on various concepts of culture and understanding of the ‘man’ within the framework of Western civilization with the help of three of their essays. In two lectures of Gadamer—‘Culture and Peace’, delivered at Salzburg in 1980, and ‘Man and His Hand in Modern Civilization’, delivered in Munich in 1978—and several essays by Emmanuel Levinas such as ‘The Philosophical Determination of the Idea of Culture’ (1983). If (...) both authors are critical of the rational based on the technique and calculation of the concept of culture inherited from the Enlightenment, and further, if this concept is embodied in the bourgeois and later in industrial societies, as retraced in the first chapter, the authors differently see the way out of the dehumanizing crisis of the modern era. (shrink)

At Statesman (Plt.) 291a–c and 303c–d, Plato compares the so-called statesmen of all existing constitutions to a motley crew of lions, centaurs, satyrs, and other beasts, and the entire section of the Statesman devoted to law and constitutions (291c–303c) to a satyr-play of sorts. This paper argues that these thought-provoking images are best understood as literary devices which, in addition to other dramatic elements in the Theaetetus and Sophist, help to bolster the unity of the Theaetetus-Sophist-Statesman trilogy and its apologetic (...) agenda concerning Socrates. (shrink)

Business Efficiency and Ethics presents both the theory of business efficiency and ethics, and a wealth of case studies based on practical experience. This unique perspective offers a framework for identifying this behaviour and reestablishing appropriate business behavior standards.

This paper analyses whether current explainable AI (XAI) techniques can help to address taxpayer concerns about the use of AI in taxation. As tax authorities around the world increase their use of AI-based techniques, taxpayers are increasingly at a loss about whether and how the ensuing decisions follow the procedures required by law and respect their substantive rights. The use of XAI has been proposed as a response to this issue, but it is still an open question whether current XAI (...) techniques are enough to meet existing legal requirements. The paper approaches this question in the context of a case study: a prototype tax fraud detector trained on an anonymized dataset of real-world cases handled by the Buenos Aires (Argentina) tax authority. The decisions produced by this detector are explained through the use of various classification methods, and the outputs of these explanation models are evaluated on their explanatory power and on their compliance with the legal obligation that tax authorities provide the rationale behind their decision-making. We conclude the paper by suggesting technical and legal approaches for designing explanation mechanisms that meet the needs of legal explanation in the tax domain. (shrink)

The paper demonstrates how Heidegger constructed his notion of an action without ends, or the ineffectual, through his early readings of Aristotle. Heidegger initially aligns the ineffectual with the notion of phronesis in Nicomachean Ethics, and later develops it further in Division 2 of Being and Time. The paper examines some of the implications of the conception of an action without ends. It shows that in fact the notion is absent from Aristotle and it is inconsistent. Finally, the paper briefly (...) explores the profound influence that the ineffectual has had on what came to be called in the United States ‘continental philosophy’. (shrink)

Through a radical new reading of the Theological Political Treatise, Dimitris Vardoulakis argues that the major source of Spinoza’s materialism is the Epicurean tradition that re-emerges in modernity when manuscripts by Epicurus and Lucretius are rediscovered. This reconsideration of Spinoza’s political project, set within a historical context, lays the ground for an alternative genealogy of materialism. Central to this new reading of Spinoza are the theory of practical judgment (understood as the calculation of utility) and its implications for a theory (...) of democracy that is resolutely positioned against authority. (shrink)

Introductory: Perspectives on Reality and "The World" in the Realism Debate One of the "characteristic parameters" dividing up analytical and Continental philosophizing is the interpretation of the concepts of "reality" and "the world". The paper offers an analysis of this characteristic parameter with regard to the relations between epistemologically centred and hermeneutically oriented doctrines of realism.

In this article, moving from being to becoming, we construe the ‘self’ as a dynamic process rather than as a static entity. To this end we draw on dialectics and Bayesian accounts of cognition. The former allows us to holistically consider the ‘self’ as the interplay between internalization and externalization and the latter to operationalize our suggestion formally. Internalization is considered here as the co-construction of bodily hierarchical models of the world and the organism, while externalization is taken as the (...) collective transformation of the world. We do not consider these processes as sequentially linked, but rather as a dialectic between the collective and the individual. This leads us to the suggestion of the self as a historical product of dialectical attunement across multiple time scales, from species evolution and culture to individual development and everyday learning. Subsequently, we describe concrete means for empirically testing our proposal in the form of two-person psychophysiology and multi-level analyses of intersubjectivity. Taken together, we suggest that a fine-grained analysis of social interaction might allow us to reconsider the ‘self’ beyond the static individual, i.e. how it emerges and manifests itself in social relations. Such an approach, we believe, could be relevant in multiple fields, from ethics and psychiatry to pedagogy and artificial intelligence. (shrink)

In this article, moving from being to becoming, we construe the ‘self’ as a dynamic process rather than as a static entity. To this end we draw on dialectics and Bayesian accounts of cognition. The former allows us to holistically consider the ‘self’ as the interplay between internalization and externalization and the latter to operationalize our suggestion formally. Internalization is considered here as the co-construction of bodily hierarchical models of the world and the organism, while externalization is taken as the (...) collective transformation of the world. We do not consider these processes as sequentially linked, but rather as a dialectic between the collective and the individual. This leads us to the suggestion of the self as a historical product of dialectical attunement across multiple time scales, from species evolution and culture to individual development and everyday learning. Subsequently, we describe concrete means for empirically testing our proposal in the form of two-person psychophysiology and multi-level analyses of intersubjectivity. Taken together, we suggest that a fine-grained analysis of social interaction might allow us to reconsider the ‘self’ beyond the static individual, i.e. how it emerges and manifests itself in social relations. Such an approach, we believe, could be relevant in multiple fields, from ethics and psychiatry to pedagogy and artificial intelligence. (shrink)

Journal of Political Philosophy, EarlyView.

This paper proposes a methodological synthesis in order to study multimodal media discourse and argumentation in the context of the so-called ‘refugee crisis’ in Greece. It follows the framework of Multimodal Critical Discourse Analysis, integrating this with argumentation studies, with a particular emphasis on the analysis of inference. Our data come from the Greek newspapers Kathimerini and Ta Nea. We contend that the proposed methodological synergy enables scrutiny of (a) racist conceptualizations cultivated by the representation of migrants and refugees in (...) headlines and photographs in newspaper articles along with (b) the argumentative potential that is implicitly sustained in these multimodal representations. (shrink)

I argue that a distinction between three autoimmunities is implied in Derrida’s _Rogues_. These are the autoimmunities of democracy as a regime of power, of democracy to come and of sovereignty. I extrapolate the relations between three different autoimmunities using the figure of the internal enemy in order to argue for an agonistic conception of democracy.

Dimitris Vardoulakis asks how it is possible to think of a politics that is not commensurate with sovereignty. For such a politics, he argues, sovereignty is defined not in terms of the exception but as the different ways in which violence is justified. Vardoulakis shows how it is possible to deconstruct the various justifications of violence. Such dejustifications can take place only by presupposing an other to sovereignty, which Vardoulakis identifies with agonistic democracy. In doing so, Sovereignty and Its Other (...) puts forward both a novel critique of sovereignty and an original philosophical theory of democratic practice. (shrink)

Le Politique est généralement conçu comme un dialogue décousu et manquant d'unité, au mieux comme une succession de méthodes et de voies de recherche différentes (division dichotomique, mythe, paradigme) visant chacune à définir le politique. Le présent article vise au contraire à montrer que l'unité du dialogue est coextensive au développement d'une unique diaíresis, et ce en soulignant, à partir de ce que le texte dit lui-même, que le mythe, la méthode par paradigme et l'analyse des constitutions existantes ne sont (...) que des moyens permettant à la division de tracer le sentier qui mène au politique tel qu'il devrait être. L'ensemble des passages méthodologiques du dialogue permet ainsi d'expliquer comment le Politique explore les possibilités et souligne les limites de la méthode diairétique. Plato's Statesman is usually read as a tedious and carelessly written exercise in dialectic, or, more charitably, as a patchwork of loosely connected applications of different methods of definition of statesmanship (division, myth and paradigm). In this paper, I argue that this much disputed problem of the unity of the dialogue can be solved, provided one reads the whole dialogue as what it claims to be, i.e. the developpment of a single diaíresis. It can be shown that the Eleatic Visitor makes use of the myth, of the analysis of paradigms and of the treatment of non-ideal constitutions as means to following a single path, throughout the whole dialogue, that leads to the definition of statesmanship as it should be. The Statesman emerges as Plato's most profound reflection on the possibilities and the limits of the diairetic method. (shrink)

The article examines the concept of duty with reference to Ibsen's play "Ghosts." It offers a brief genealogy of duty while linking the concept of duty to a deconstructive approach.

Medical practice is ideally based on robust, relevant research. However, the lack of disease-modifying treatments for Alzheimer’s disease has motivated “innovative practice” to improve patients’ well-being despite insufficient evidence for the regular use of such interventions in health systems treating millions of patients. Innovative or new non-validated practice poses at least three distinct ethical questions: first, about the responsible application of new non-validated practice to individual patients ; second, about the way in which data from new non-validated practice are communicated (...) via the scientific and lay press ; and third, about the prospect of making new non-validated interventions widely available before more definitive testing. We argue that the authors of metabolic enhancement protocols for Alzheimer’s disease have overstated the evidence in favor of these interventions within the scientific and lay press, failing to communicate weaknesses in their data and uncertainty about their conclusions. Such unmeasured language may create false hope, cause financial harm, undermine informed consent, and frustrate the production of generalizable knowledge necessary to face the societal problems posed by this devastating disease. We therefore offer more stringent guidelines for responsible innovation in the treatment of Alzheimer’s disease. (shrink)